Open postdoctoral position, faculty mentor Christopher Kassotis

Summary

A new laboratory is now open at Wayne State that seeks to evaluate how common consumer product chemicals (flame retardants, phthalates, etc.) and their mixtures may interfere with the body's endocrine system following exposure. The Kassotis Lab is interested in how exposure to these chemicals (and mixtures of these chemicals) may disrupt metabolic health and contribute to or exacerbate obesity and other metabolic disorders. We will pursue these aims through mechanistic cell culture experiments and medium-throughput zebrafish exposure and imaging experiments. Our ultimate goals are to assess potential human health effects following exposure to diverse environmental contaminants and mixtures. Qualified applicants will support R00 (NIEHS)-funded experiments to achieve several key aims:

  1. Assessing metabolic health impacts of polyethoxylated surfactants in cell and animal models
  2. Determining causal mechanisms for these impacts across both human and zebrafish cell assays
  3. Assessing relative contribution(s) of polyethoxylated surfactants to environmental sample-induced metabolic disruption Successful applications will also be encouraged to get involved with a variety of pilot experiments, and will develop their own research projects within the overall laboratory research focus. They will publish research results, be supported to present at scientific meetings each year, and will be encouraged/supported to apply for grants to support postdoctoral research and foster their own research interests and career development.

Required qualifications

  • Recent graduates with a Ph.D. in biology, endocrinology, toxicology, environmental health, molecular/cellular biology, chemistry, or related fields are encouraged to apply.
  • Previous tissue culture experience working with human/animal cell lines is a plus, as a major component of this laboratory will be cell-based and cell-free mechanistic assays. Previous experience working with zebrafish is a plus, as the laboratory will be setting up a small zebrafish housing system to support metabolic health and endocrine disrupting chemical testing. Previous experience working with CRISPR and other genetic manipulation techniques in cell and animal models is encouraged to support R00 experiments and other pilot projects. Applicants are encouraged to apply even without these skills, as training opportunities are readily available and plenty of hands-on experience is available.

Required application materials

  • Cover letter (1 page detailing your overall qualifications and interest in lab)
  • Curriculum vitae (CV)
  • Statement of research interests (1-2 pages on your research to date, interests, and how your experience and research interests fit into the overall lab focus and your career development). 

Please submit the application materials as a single PDF by email to Dr. Kassotis, christopher.kassotis@wayne.edu